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Long-distance Axonal Transport of AAV9 Is Driven by Dynein and Kinesin-2 and Is Trafficked in a Highly Motile Rab7-positive Compartment

Adeno-associated virus (AAV) vectors can move along axonal pathways after brain injection, resulting in transduction of distal brain regions. This can enhance the spread of therapeutic gene transfer and improve treatment of neurogenetic disorders that require global correction. To better understand...

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Detalhes bibliográficos
Main Authors: Castle, Michael J, Perlson, Eran, Holzbaur, Erika LF, Wolfe, John H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944332/
https://ncbi.nlm.nih.gov/pubmed/24100640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.237
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