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Long-distance Axonal Transport of AAV9 Is Driven by Dynein and Kinesin-2 and Is Trafficked in a Highly Motile Rab7-positive Compartment

Adeno-associated virus (AAV) vectors can move along axonal pathways after brain injection, resulting in transduction of distal brain regions. This can enhance the spread of therapeutic gene transfer and improve treatment of neurogenetic disorders that require global correction. To better understand...

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Bibliografische gegevens
Hoofdauteurs: Castle, Michael J, Perlson, Eran, Holzbaur, Erika LF, Wolfe, John H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944332/
https://ncbi.nlm.nih.gov/pubmed/24100640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.237
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