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Dynein drives nuclear rotation during forward progression of motile fibroblasts

During directed cell migration the movement of the nucleus is coupled to the forward progression of the cell. The microtubule motor cytoplasmic dynein is required for both cell polarization and cell motility. Here, we investigate the mechanism by which dynein contributes to directed migration. Knock...

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Detalhes bibliográficos
Main Authors: Levy, Jennifer R., Holzbaur, Erika L.F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819424/
https://ncbi.nlm.nih.gov/pubmed/18782860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.033878
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