TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η

We previously identified a Drosophila maternal effect-lethal mutant named ‘no poles’ (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles during the rapid cycles of syncytial embryogenesis because of activation of a Chk2-mediated DNA checkpoint. NOPO is...

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Detalhes bibliográficos
Main Authors: Wallace, Heather A., Merkle, Julie A., Yu, Michael C., Berg, Taloa G., Lee, Ethan, Bosco, Giovanni, Lee, Laura A.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943184/
https://ncbi.nlm.nih.gov/pubmed/24553286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.101196
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