4′-O-substitutions determine selectivity of aminoglycoside antibiotics

Clinical use of 2-deoxystreptamine aminoglycoside antibiotics, which target the bacterial ribosome, is compromised by adverse effects related to limited drug selectivity. Here we present a series of 4′,6′-O-acetal and 4′-O-ether modifications on glucopyranosyl ring I of aminoglycosides. Chemical mod...

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Bibliografiske detaljer
Main Authors: Perez-Fernandez, Déborah, Shcherbakov, Dmitri, Matt, Tanja, Leong, Ng Chyan, Kudyba, Iwona, Duscha, Stefan, Boukari, Heithem, Patak, Rashmi, Dubbaka, Srinivas Reddy, Lang, Kathrin, Meyer, Martin, Akbergenov, Rashid, Freihofer, Pietro, Vaddi, Swapna, Thommes, Pia, Ramakrishnan, V., Vasella, Andrea, Böttger, Erik C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942853/
https://ncbi.nlm.nih.gov/pubmed/24473108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4112
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