Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...

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Detalhes bibliográficos
Main Authors: Nofsinger, Rebecca, Clas, Sophie-Dorothee, Sanchez, Rosa I., Walji, Abbas, Manser, Kimberly, Nissley, Becky, Balsells, Jaume, Nair, Amrithraj, Dang, Qun, Bennett, David Jonathan, Hafey, Michael, Wang, Junying, Higgins, John, Templeton, Allen, Coleman, Paul, Grobler, Jay, Smith, Ronald, Wu, Yunhui
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942693/
https://ncbi.nlm.nih.gov/pubmed/24566521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph7020207
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