Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Nofsinger, Rebecca, Clas, Sophie-Dorothee, Sanchez, Rosa I., Walji, Abbas, Manser, Kimberly, Nissley, Becky, Balsells, Jaume, Nair, Amrithraj, Dang, Qun, Bennett, David Jonathan, Hafey, Michael, Wang, Junying, Higgins, John, Templeton, Allen, Coleman, Paul, Grobler, Jay, Smith, Ronald, Wu, Yunhui
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI 2014
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942693/
https://ncbi.nlm.nih.gov/pubmed/24566521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph7020207
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