Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...

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Autors principals: Nofsinger, Rebecca, Clas, Sophie-Dorothee, Sanchez, Rosa I., Walji, Abbas, Manser, Kimberly, Nissley, Becky, Balsells, Jaume, Nair, Amrithraj, Dang, Qun, Bennett, David Jonathan, Hafey, Michael, Wang, Junying, Higgins, John, Templeton, Allen, Coleman, Paul, Grobler, Jay, Smith, Ronald, Wu, Yunhui
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942693/
https://ncbi.nlm.nih.gov/pubmed/24566521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph7020207
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