Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia

BACKGROUND: TP53 mutation/deletion is uncommon in chronic lymphocytic leukemia (CLL). We postulated that components of TP53-centered tumor suppressor network, miR-34b/c, in addition to DAPK1 and miR-34a might be inactivated by DNA hypermethylation. Moreover, we tested if miR-34b/c methylation might...

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Autori principali: Wang, Lu Qian, Kwong, Yok Lam, Wong, Kit Fai, Kho, Chi Shan Bonnie, Jin, Dong Yan, Tse, Eric, Rosèn, Anders, Chim, Chor Sang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941938/
https://ncbi.nlm.nih.gov/pubmed/24559316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-52
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