Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia - implications on constitutive activation of NFκB pathway

BACKGROUND: The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. We postulated that miR-9-1, miR-9-2 and miR-9-3 might be inactivated by DNA hypermethylation in chronic lymphocytic leukemia (CLL). METHODS: Methylation of miR-9-1, miR-9-2 and miR-9-3 was studied in...

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Detalhes bibliográficos
Main Authors: Wang, Lu Qian, Kwong, Yok Lam, Kho, Chi Shan Bonnie, Wong, Kit Fai, Wong, Kwan Yeung, Ferracin, Manuela, Calin, George A, Chim, Chor Sang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877874/
https://ncbi.nlm.nih.gov/pubmed/24373626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-173
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