Epigenetic Inactivation of the miR-124-1 in Haematological Malignancies

miR-124-1 is a tumour suppressor microRNA (miR). Epigenetic deregulation of miRs is implicated in carcinogenesis. Promoter DNA methylation and histone modification of miR-124-1 was studied in 5 normal marrow controls, 4 lymphoma, 8 multiple myeloma (MM) cell lines, 230 diagnostic primary samples of...

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Autors principals: Wong, Kwan Yeung, So, Chi Chiu, Loong, Florence, Chung, Lap Ping, Lam, William Wai Lung, Liang, Raymond, Li, George Kam Hop, Jin, Dong-Yan, Chim, Chor Sang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081325/
https://ncbi.nlm.nih.gov/pubmed/21544199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019027
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