Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms

BACKGROUND: MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis. METHODS: We studied DNA methylation of these miRs in Philadelphia-negative (Ph-ve) myeloproliferative neoplasms (MPNs). Methylation-specific PCR (MSP), verified by direct sequencing of...

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Bibliografiske detaljer
Main Authors: Chim, Chor Sang, Wan, Thomas S, Wong, Kwan Yeung, Fung, Tsz Kin, Drexler, Hans G, Wong, Kit Fai
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283527/
https://ncbi.nlm.nih.gov/pubmed/22082000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-197
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