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Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

The 5′ cap of human messenger RNA contains 2′-O-methylation of the first and often second transcribed nucleotide that is important for its processing, translation and stability. Human enzymes that methylate these nucleotides, termed CMTr1 and CMTr2, respectively, have recently been identified. Howev...

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Autores principales: Smietanski, Miroslaw, Werner, Maria, Purta, Elzbieta, Kaminska, Katarzyna H., Stepinski, Janusz, Darzynkiewicz, Edward, Nowotny, Marcin, Bujnicki, Janusz M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941023/
https://ncbi.nlm.nih.gov/pubmed/24402442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4004
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