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Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase

[Image: see text] A series of α-ketooxazoles incorporating electrophiles at the C5 position of the pyridyl ring of 2 (OL-135) and related compounds were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH) that additionally target the cytosolic port Cys269. From this series, a su...

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Main Authors: Otrubova, Katerina, Cravatt, Benjamin F., Boger, Dale L.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940414/
https://ncbi.nlm.nih.gov/pubmed/24456116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401820q
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