Evidence for Ongoing DNA Damage in Multiple Myeloma Cells as Revealed by Constitutive Phosphorylation of H2AX

DNA double strand breaks (DSBs) are deleterious lesions that can lead to chromosomal anomalies, genomic instability and cancer. The histone protein H2AX plays an important role in the DNA damage response (DDR) and the presence of phospho-H2AX (γH2AX) nuclear foci is the hallmark of DSBs. We hypothes...

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Main Authors: Walters, Denise K., Wu, Xiaosheng, Tschumper, Renee C., Arendt, Bonnie K., Huddleston, Paul M., Henderson, Kimberly J., Dispenzieri, Angela, Jelinek, Diane F.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940337/
https://ncbi.nlm.nih.gov/pubmed/21566653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.94
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