Comprehensive Assessment of Potential Multiple Myeloma Immunoglobulin Heavy Chain V-D-J Intraclonal Variation Using Massively Parallel Pyrosequencing

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells (PCs) in the bone marrow (BM). MM is viewed as a clonal disorder due to lack of verified intraclonal sequence diversity in the immunoglobulin heavy chain variable region gene (IGHV). However, this conclusion is base...

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Hauptverfasser: Tschumper, Renee C., Asmann, Yan W., Hossain, Asif, Huddleston, Paul M., Wu, Xiaosheng, Dispenzieri, Angela, Eckloff, Bruce W., Jelinek, Diane F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2012
Schlagworte:
Methodological Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380583/
https://ncbi.nlm.nih.gov/pubmed/22522905
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