Sequence specificity of actinomycin D and Netropsin binding to pBR322 DNA analyzed by protection from DNase I.

A direct approach to determining the sequence specificities of equilibrium binding drugs by using the DNase protection technique is described. The method utilizes singly end-labeled restriction fragments and partial digestion of the drug fragment complex with DNase I. Microdensitometry of autoradiog...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Lane, M J, Dabrowiak, J C, Vournakis, J N
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1983
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394020/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6304702/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.11.3260
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