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Conserved Hydrogen Bonding Networks of MitoNEET Tune FeS Cluster Binding and Structural Stability

While its biological function remains unclear, the 3-Cys, 1-His ligated human [2Fe-2S] cluster containing protein mitoNEET is of interest due to its interaction with the anti-diabetes drug pioglitazone. The mitoNEET [2Fe-2S] cluster demonstrates proton coupled-electron transfer (PCET) and marked clu...

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Bibliografiske detaljer
Main Authors: Bak, Daniel W., Elliott, Sean J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940166/
https://ncbi.nlm.nih.gov/pubmed/23758282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400540m
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