Mutation of the His ligand in mitoNEET stabilizes the 2Fe–2S cluster despite conformational heterogeneity in the ligand environment

MitoNEET is the only identified Fe–S protein localized to the outer mitochondrial membrane and a 1.5 Å resolution X-ray analysis has revealed a unique structure [Paddock et al. (2007 ▶), Proc. Natl Acad. Sci. USA, 104, 14342–14347]. The 2Fe–2S cluster is bound with a 3Cys–1His coordination which def...

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Bibliographic Details
Main Authors: Conlan, Andrea R., Paddock, Mark L., Homer, Christina, Axelrod, Herbert L., Cohen, Aina E., Abresch, Edward C., Zuris, John A., Nechushtai, Rachel, Jennings, Patricia A.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2011
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107049/
https://ncbi.nlm.nih.gov/pubmed/21636891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011577
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