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Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer

OBJECTIVES: Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic phenotype in preclinical cancer studies. We designed this open label phase II trial to determine the response rate, safety,...

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Hlavní autoři: Garon, Edward B., Christofk, Heather R., Hosmer, Wylie, Britten, Carolyn D, Bahng, Agnes, Crabtree, Matthew J, Hong, Candice Sun, Kamranpour, Naeimeh, Pitts, Sharon, Kabbinavar, Fairooz, Patel, Cecil, von Euw, Erika, Black, Alexander, Michelakis, Evangelos D., Dubinett, Steven M., Slamon, Dennis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939783/
https://ncbi.nlm.nih.gov/pubmed/24442098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-014-1583-9
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