Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer

OBJECTIVES: Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic phenotype in preclinical cancer studies. We designed this open label phase II trial to determine the response rate, safety,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Garon, Edward B., Christofk, Heather R., Hosmer, Wylie, Britten, Carolyn D, Bahng, Agnes, Crabtree, Matthew J, Hong, Candice Sun, Kamranpour, Naeimeh, Pitts, Sharon, Kabbinavar, Fairooz, Patel, Cecil, von Euw, Erika, Black, Alexander, Michelakis, Evangelos D., Dubinett, Steven M., Slamon, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939783/
https://ncbi.nlm.nih.gov/pubmed/24442098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-014-1583-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados