In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds

PURPOSE: Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a pa...

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Bibliographic Details
Main Authors: Olszewski, Ulrike, Poulsen, Thomas Tuxen, Ulsperger, Ernst, Poulsen, Hans Skovgard, Geissler, Klaus, Hamilton, Gerhard
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2010
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262384/
https://ncbi.nlm.nih.gov/pubmed/22291503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S11795
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