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In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds
PURPOSE: Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a pa...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262384/ https://ncbi.nlm.nih.gov/pubmed/22291503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S11795 |
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