In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds

PURPOSE: Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a pa...

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Detaylı Bibliyografya
Asıl Yazarlar: Olszewski, Ulrike, Poulsen, Thomas Tuxen, Ulsperger, Ernst, Poulsen, Hans Skovgard, Geissler, Klaus, Hamilton, Gerhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2010
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262384/
https://ncbi.nlm.nih.gov/pubmed/22291503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S11795
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