In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds

PURPOSE: Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a pa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Olszewski, Ulrike, Poulsen, Thomas Tuxen, Ulsperger, Ernst, Poulsen, Hans Skovgard, Geissler, Klaus, Hamilton, Gerhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Dove Medical Press 2010
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262384/
https://ncbi.nlm.nih.gov/pubmed/22291503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S11795
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