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Enhanced Cell Surface Stability of Rescued ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator by Pharmacological Chaperones
Misfolded proteins destined for the cell surface are recognized and degraded by the ER-associated degradative (ERAD) pathway. Temperature-sensitive (TS) mutants at permissive temperature escape ERAD and reach the cell surface. Here, we examined a TS mutant of the cystic fibrosis transmembrane conduc...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939615/ https://ncbi.nlm.nih.gov/pubmed/18052931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071420 |
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