Enhanced Cell Surface Stability of Rescued ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator by Pharmacological Chaperones

Misfolded proteins destined for the cell surface are recognized and degraded by the ER-associated degradative (ERAD) pathway. Temperature-sensitive (TS) mutants at permissive temperature escape ERAD and reach the cell surface. Here, we examined a TS mutant of the cystic fibrosis transmembrane conduc...

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Detalhes bibliográficos
Main Authors: Varga, K, Goldstein, RF, Jurkuvenaite, A, Chen, L, Matalon, S, Sorscher, EJ, Bebok, Z, Collawn, JF
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939615/
https://ncbi.nlm.nih.gov/pubmed/18052931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071420
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