Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter

N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase. Both WT- and E3-defective C329S-HRD1 decreased the level of high mannose form of ABCG8, a protein that heterodim...

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Main Authors: Suzuki, Shingo, Shuto, Tsuyoshi, Sato, Takashi, Kaneko, Masayuki, Takada, Tappei, Suico, Mary Ann, Cyr, Douglas M., Suzuki, Hiroshi, Kai, Hirofumi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939451/
https://ncbi.nlm.nih.gov/pubmed/24584735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04258
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