Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

The timing and localization of events during mitosis is controlled by the regulated phosphorylation of proteins by the mitotic kinases, which include Aurora A, Aurora B, Nek2, Plk1, and the cyclin-dependent kinase complex Cdk1/cyclin B. Although mitotic kinases can have overlapping subcellular local...

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Main Authors: Alexander, Jes, Lim, Daniel, Joughin, Brian A., Hegemann, Björn, Hutchins, James R. A., Ehrenberger, Tobias, Ivins, Frank, Sessa, Fabio, Hudecz, Otto, Nigg, Erich A., Fry, Andrew M., Musacchio, Andrea, Stukenberg, P. Todd, Mechtler, Karl, Peters, Jan-Michael, Smerdon, Stephen J., Yaffe, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939359/
https://ncbi.nlm.nih.gov/pubmed/21712545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001796
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