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Exclusive destruction of mitotic spindles in human cancer cells

We identified target proteins modified by phenanthrenes that cause exclusive eradication of human cancer cells. The cytotoxic activity of the phenanthrenes in a variety of human cancer cells is attributed by these findings to post translational modifications of NuMA and kinesins HSET/kifC1 and kif18...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Visochek, Leonid, Castiel, Asher, Mittelman, Leonid, Elkin, Michael, Atias, Dikla, Golan, Talia, Izraeli, Shai, Peretz, Tamar, Cohen-Armon, Malka
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400547/
https://ncbi.nlm.nih.gov/pubmed/28209915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15343
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