Quantitative Phospho-proteomics to Investigate the Polo-like Kinase 1-Dependent Phospho-proteome

Polo-like kinase 1 (PLK1) is a key regulator of mitotic progression and cell division, and small molecule inhibitors of PLK1 are undergoing clinical trials to evaluate their utility in cancer therapy. Despite this importance, current knowledge about the identity of PLK1 substrates is limited. Here w...

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Detalhes bibliográficos
Main Authors: Grosstessner-Hain, Karin, Hegemann, Björn, Novatchkova, Maria, Rameseder, Jonathan, Joughin, Brian A., Hudecz, Otto, Roitinger, Elisabeth, Pichler, Peter, Kraut, Norbert, Yaffe, Michael B., Peters, Jan-Michael, Mechtler, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226402/
https://ncbi.nlm.nih.gov/pubmed/21857030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.008540
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