Quantitative Phospho-proteomics to Investigate the Polo-like Kinase 1-Dependent Phospho-proteome

Polo-like kinase 1 (PLK1) is a key regulator of mitotic progression and cell division, and small molecule inhibitors of PLK1 are undergoing clinical trials to evaluate their utility in cancer therapy. Despite this importance, current knowledge about the identity of PLK1 substrates is limited. Here w...

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Autors principals: Grosstessner-Hain, Karin, Hegemann, Björn, Novatchkova, Maria, Rameseder, Jonathan, Joughin, Brian A., Hudecz, Otto, Roitinger, Elisabeth, Pichler, Peter, Kraut, Norbert, Yaffe, Michael B., Peters, Jan-Michael, Mechtler, Karl
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226402/
https://ncbi.nlm.nih.gov/pubmed/21857030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.008540
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