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Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects
Metazoans limit origin firing to once per cell cycle by oscillations in cyclin-dependent kinases and the replication licensing inhibitor geminin. Geminin inhibits pre-replication complex assembly by preventing Cdt1 from recruiting the minichromosome maintenance proteins to chromatin. Geminin depleti...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1371027/ https://ncbi.nlm.nih.gov/pubmed/16179947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400527 |
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