Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development

In multicellular eukaryotes, geminin prevents overreplication of DNA in proliferating cells. Here, we show that genetic ablation of geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells. All cells in geminin-defic...

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Detalhes bibliográficos
Main Authors: Gonzalez, Michael A., Tachibana, Kiku-e K., Adams, David J., van der Weyden, Louise, Hemberger, Myriam, Coleman, Nicholas, Bradley, Allan, Laskey, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1522086/
https://ncbi.nlm.nih.gov/pubmed/16847348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.379706
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