Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development

In multicellular eukaryotes, geminin prevents overreplication of DNA in proliferating cells. Here, we show that genetic ablation of geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells. All cells in geminin-defic...

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Détails bibliographiques
Auteurs principaux: Gonzalez, Michael A., Tachibana, Kiku-e K., Adams, David J., van der Weyden, Louise, Hemberger, Myriam, Coleman, Nicholas, Bradley, Allan, Laskey, Ronald A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2006
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1522086/
https://ncbi.nlm.nih.gov/pubmed/16847348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.379706
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