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Geminin Is Essential for Pluripotent Cell Viability During Teratoma Formation, but Not for Differentiated Cell Viability During Teratoma Expansion

Pluripotent embryonic stem cells (ESCs) are unusual in that geminin has been reported to be essential either to prevent differentiation by maintaining expression of pluripotency genes or to prevent DNA rereplication-dependent apoptosis. To distinguish between these two incompatible hypotheses, immun...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Adler-Wailes, Diane C., Kramer, Joshua A., DePamphilis, Melvin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312595/
https://ncbi.nlm.nih.gov/pubmed/27821018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0260
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