Lack of Z-DNA conformation in mitomycin-modified polynucleotides having inverted circular dichroism.
Poly(dG-dC) . poly(dG-dC) and Micrococcus lysodeikticus DNA were modified by exposure to reductively activated mitomycin C, an antitumor antibiotic. The resulting covalent drug-polynucleotide complexes displayed varying degrees of CD inversions, which are strikingly similar to the inverted spectrum...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1983
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6574457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.10.2874 |
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