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Lack of Z-DNA conformation in mitomycin-modified polynucleotides having inverted circular dichroism.

Poly(dG-dC) . poly(dG-dC) and Micrococcus lysodeikticus DNA were modified by exposure to reductively activated mitomycin C, an antitumor antibiotic. The resulting covalent drug-polynucleotide complexes displayed varying degrees of CD inversions, which are strikingly similar to the inverted spectrum...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tomasz, M, Barton, J K, Magliozzo, C C, Tucker, D, Lafer, E M, Stollar, B D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1983
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393935/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6574457/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.10.2874
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