Lack of Z-DNA conformation in mitomycin-modified polynucleotides having inverted circular dichroism.
Poly(dG-dC) . poly(dG-dC) and Micrococcus lysodeikticus DNA were modified by exposure to reductively activated mitomycin C, an antitumor antibiotic. The resulting covalent drug-polynucleotide complexes displayed varying degrees of CD inversions, which are strikingly similar to the inverted spectrum...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1983
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6574457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.10.2874 |
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