Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells

AIMS/HYPOTHESIS: Incretin therapies, which are used to treat diabetic patients, cause a chronic supra-physiological increase in GLP-1 circulating levels. It is still unclear how the resulting high hormone concentrations may affect pancreatic alpha cells. The present study was designed to investigate...

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Detalhes bibliográficos
Main Authors: Piro, Salvatore, Mascali, Loriana G., Urbano, Francesca, Filippello, Agnese, Malaguarnera, Roberta, Calanna, Salvatore, Rabuazzo, Agata M., Purrello, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938588/
https://ncbi.nlm.nih.gov/pubmed/24587221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090093
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