Chronic Exposure to Palmitate Impairs Insulin Signaling in an Intestinal L-cell Line: A Possible Shift from GLP-1 to Glucagon Production

Obesity and type 2 diabetes mellitus (T2DM) are characterized by insulin resistance and impaired glucagon-like peptide-1 (GLP-1) secretion/function. Lipotoxicity, a chronic elevation of free fatty acids in the blood, could affect insulin-signaling in many peripheral tissues. To date, the effects of...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Filippello, Agnese, Urbano, Francesca, Di Mauro, Stefania, Scamporrino, Alessandra, Di Pino, Antonino, Scicali, Roberto, Rabuazzo, Agata Maria, Purrello, Francesco, Piro, Salvatore
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321596/
https://ncbi.nlm.nih.gov/pubmed/30487448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19123791
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