Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress

Statins are a class of drugs widely prescribed as frontline therapy for lowering plasma LDL-cholesterol in cardiovascular risk prevention. Several clinical reports have recently suggested an increased risk of type 2 diabetes associated with chronic use of these drugs. The pathophysiology of this eff...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Urbano, Francesca, Bugliani, Marco, Filippello, Agnese, Scamporrino, Alessandra, Di Mauro, Stefania, Di Pino, Antonino, Scicali, Roberto, Noto, Davide, Rabuazzo, Agata Maria, Averna, Maurizio, Marchetti, Piero, Purrello, Francesco, Piro, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605712/
https://ncbi.nlm.nih.gov/pubmed/28928397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11070-x
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