Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (α-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells.

Incretin therapies, which are used to treat diabetic patients, cause a chronic supra-physiological increase in GLP-1 circulating levels. It is still unclear how the resulting high hormone concentrations may affect pancreatic alpha cells. The present study was designed to investigate the effects of c...

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Detalhes bibliográficos
Main Authors: Salvatore Piro, Loriana G Mascali, Francesca Urbano, Agnese Filippello, Roberta Malaguarnera, Salvatore Calanna, Agata M Rabuazzo, Francesco Purrello
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3938588?pdf=render
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