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Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery
Conventional orthosteric drug development programs targeting G protein-coupled receptors (GPCRs) have focused on the concepts of agonism and antagonism, in which receptor structure determines the nature of the downstream signal and ligand efficacy determines its intensity. Over the past decade, the...
में बचाया:
| मुख्य लेखक: | |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Endocrine Society
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938544/ https://ncbi.nlm.nih.gov/pubmed/24433041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1314 |
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