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Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery
Conventional orthosteric drug development programs targeting G protein-coupled receptors (GPCRs) have focused on the concepts of agonism and antagonism, in which receptor structure determines the nature of the downstream signal and ligand efficacy determines its intensity. Over the past decade, the...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Endocrine Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938544/ https://ncbi.nlm.nih.gov/pubmed/24433041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1314 |
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