Isolation and expression of an altered mouse dihydrofolate reductase cDNA.
We have constructed a cDNA library from a murine cell line expressing high levels of a dihydrofolate reductase (tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3) that displays an abnormally low affinity for methotrexate. From this library we have isolated a c...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1983
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6573667/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.9.2495 |
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