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Expression of dihydrofolate reductase, and of the adjacent EIb region, in an Ad5-dihydrofolate reductase recombinant virus.

A gene with the Ad2 MLP and first leader, and appropriate RNA processing signals (splicing, polyadenylation) positioned around a mouse DHFR cDNA clone was substituted for the EIa region of Ad5, and virus stocks of Ad5 (DHFR-I) were prepared on 293 cells. A DHFR RNA of the expected size and structure...

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Autors principals: Berkner, K L, Sharp, P A
Format: Artigo
Idioma:Inglês
Publicat: 1984
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC318631/
https://ncbi.nlm.nih.gov/pubmed/6199745
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