Structure-guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

Engineered analog-sensitive (AS) protein kinases have emerged as powerful tools for dissecting phospho-signaling pathways, for elucidating the cellular function of individual kinases, and for deciphering unanticipated effects of clinical therapeutics. A crucial and necessary feature of this technolo...

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Главные авторы: Zhang, Chao, Lopez, Michael S., Dar, Arvin C., LaDow, Eva, Finkbeiner, Steven, Yun, Cai-Hong, Eck, Michael J., Shokat, Kevan M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938192/
https://ncbi.nlm.nih.gov/pubmed/23841803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400376p
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