Explorations of Substituted Urea Functionality for Discovery of New Activators of the Heme Regulated Inhibitor Kinase

Heme-regulated inhibitor kinase (HRI), an eukaryotic translation initiation factor 2 alpha (eIF2α) kinase, plays critical roles in cell proliferation, differentiation, and adaptation to cytoplasmic stress. HRI is also a critical modifier of hemoglobin disorders such as β-thalassemia. We previously i...

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Main Authors: Chen, Ting, Takrouri, Khuloud, Hee-Hwang, Sung, Rana, Sandeep, Yefidoff-Freedman, Revital, Halperin, Jose, Natarajan, Amarnath, Morisseau, Christophe, Hammock, Bruce, Chorev, Michael, Aktas, Bertal H.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938169/
https://ncbi.nlm.nih.gov/pubmed/24261904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400793v
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