Activation of Nox4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival during Energy Stress through the PERK/eIF-2α/ATF4 pathway

RATIONALE: Autophagy is an essential survival mechanism during energy stress in the heart. Oxidative stress is activated by energy stress, but its role in mediating autophagy is poorly understood. Nox4 is an enzyme that generates reactive oxygen species (ROS) at intracellular membranes. Whether Nox4...

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Main Authors: Sciarretta, Sebastiano, Zhai, Peiyong, Shao, Dan, Zablocki, Daniela, Nagarajan, Narayani, Terada, Lance S., Volpe, Massimo, Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937770/
https://ncbi.nlm.nih.gov/pubmed/24081881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301787
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