Mitochondria-targeted Ogg1 and Aconitase-2 Prevent Oxidant-induced Mitochondrial DNA Damage in Alveolar Epithelial Cells

Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each reduce oxidant-induced alveolar epithelial cell (AEC) apoptosis, but it is unclear whether protection occurs by preventing AEC mitochondrial DNA (mtDNA) damage. Using quantitative PCR-based measurements...

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Detalhes bibliográficos
Main Authors: Kim, Seok-Jo, Cheresh, Paul, Williams, David, Cheng, Yuan, Ridge, Karen, Schumacker, Paul T., Weitzman, Sigmund, Bohr, Vilhelm A., Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937682/
https://ncbi.nlm.nih.gov/pubmed/24429287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515130
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