ROLE OF MITOCHONDRIAL hOGG1 AND ACONITASE IN OXIDANT-INDUCED LUNG EPITHELIAL CELL APOPTOSIS

8-oxoguanine DNA glycosylase (Oggl) repairs 8-oxo-7,8-dihydroxyguanine (8-oxoG), one of the most abundant DNA adducts caused by oxidative stress. In the mitochondria, Oggl is thought to prevent activation of the intrinsic apoptotic pathway in response to oxidative stress by augmenting DNA repair. Ho...

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Publicado en:Free Radic Biol Med
Main Authors: Panduri, V, Liu, G, Surapureddi, S, Kondapalli, J, Soberanes, S, de Souza-Pinto, NC, Bohr, VA, Budinger, GRS, Schumacker, PT, Weitzman, SA, Kamp, DW
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331123/
https://ncbi.nlm.nih.gov/pubmed/19524665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.06.010
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