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P53 Mediates Amosite Asbestos–Induced Alveolar Epithelial Cell Mitochondria-Regulated Apoptosis
Asbestos causes pulmonary toxicity in part by generating reactive oxygen species that cause DNA damage. We previously showed that the mitochondria-regulated (intrinsic) death pathway mediates alveolar epithelial cell (AEC) DNA damage and apoptosis. Because p53 regulates the DNA damage response in pa...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Thoracic Society
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644206/ https://ncbi.nlm.nih.gov/pubmed/16357363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0352OC |
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