p53 Mediates Particulate Matter–induced Alveolar Epithelial Cell Mitochondria-regulated Apoptosis

Rationale: Exposure to particulate matter (PM) causes lung cancer by mechanisms that are unknown, but p53 dysfunction is implicated. Objective: We determined whether p53 is required for PM-induced apoptosis in both human and rodent alveolar type (AT) 2 cells. Methods: A well-characterized form of ur...

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Detalhes bibliográficos
Main Authors: Soberanes, Saul, Panduri, Vijayalakshmi, Mutlu, Gökhan M., Ghio, Andrew, Bundinger, G. R. Scott, Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2006
Assuntos:
E. Environmental and Occupational Lung Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648105/
https://ncbi.nlm.nih.gov/pubmed/16946128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200602-203OC
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