Mitochondrial Complex III-generated Oxidants Activate ASK1 and JNK to Induce Alveolar Epithelial Cell Death following Exposure to Particulate Matter Air Pollution

We have previously reported that airborne particulate matter air pollution (PM) activates the intrinsic apoptotic pathway in alveolar epithelial cells through a pathway that requires the mitochondrial generation of reactive oxygen species (ROS) and the activation of p53. We sought to examine the sou...

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Autori principali: Soberanes, Saul, Urich, Daniela, Baker, Christina M., Burgess, Zach, Chiarella, Sergio E., Bell, Eric L., Ghio, Andrew J., De Vizcaya-Ruiz, Andrea, Liu, Jing, Ridge, Karen M., Kamp, David W., Chandel, Navdeep S., Schumacker, Paul T., Mutlu, Gökhan M., Budinger, G. R. Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629089/
https://ncbi.nlm.nih.gov/pubmed/19033436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808844200
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